Magnesium diminishes stroke risk: Am J Clin Nutr

Am J Clin Nutr. 2011 Dec 28. [Epub ahead of print]

Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies.

Larsson SC, Orsini N, Wolk A.


Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.



Prospective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results.Objective We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk.


Relevant studies were identified by searching PubMed and EMBASE from January 1966 through September 2011 and reviewing reference lists of retrieved articles. We included prospective studies that reported RRs with 95% CIs of stroke for ≥3 categories of magnesium intake. Results from individual studies were combined by using a random-effects model.


Seven prospective studies, with 6477 cases of stroke and 241,378 participants were eligible for inclusion in the meta-analysis. We observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg Mg/d was associated with an 8% reduction in risk of total stroke (combined RR: 0.92; 95% CI: 0.88, 0.97), without heterogeneity among studies (P = 0.66, I(2) = 0%). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91; 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96; 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01; 95% CI: 0.90, 1.14).


Dietary magnesium intake is inversely associated with risk of stroke, specifically ischemic stroke.

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