Category Archives: Metformin

Metformin as a potential treatment for the rare pediatric disorder, maple syrup urine disease, MSUD






Maple Syrup Urine Disease (MSUD) is a rare inherited metabolic disorder involving the dysfunction of an enzyme which breaks down three essential amino acids: leucine, isoleucine and valine. Left untreated, infants die from a toxic buildup of resulting keto-acids within … Continue reading






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Metformin tied to risk of B12 deficiency: NIH






(Reuters Health) – - People taking metformin, a common type 2 diabetes medication, for several years may be at heightened risk of vitamin B12 deficiency and anemia, according to a new analysis of long-term data. Metformin helps to control the … Continue reading






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How diabetes drug metformin inhibits progression of pancreatic cancer






Massachusetts General Hospital (MGH) investigators may have uncovered a novel mechanism behind the ability of the diabetes drug metformin to inhibit the progression of pancreatic cancer. In their report that has been published in the open access journal PLOS One, … Continue reading






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Rosiglitazone-containing Diabetes Medicines: FDA Eliminates the Risk Evaluation and Mitigation Strategy (REMS)






AUDIENCE: Family Practice, Endocrinology, Cardiology ISSUE: FDA is eliminating the Risk Evaluation and Mitigation Strategy (REMS) for rosiglitazone-containing type 2 diabetes medicines, which are approved as Avandia, Avandamet, Avandaryl, and generics. The REMS is no longer necessary to ensure that … Continue reading






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Metformin, the diabetes drug, may also delay aging






In a slew of recent flashy endeavors, scientists, academics and exceptionally rich people have taken on the aging process. In 2013, Google launched Calico, its billion-dollar anti-aging research and development arm, which the following year formed a partnership with pharmaceutical … Continue reading






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Metformin, thought to help prevent prostate cancer in diabetics, to be studied






Newswise — New Brunswick, N.J., August 31, 2015 – Rutgers Cancer Institute of New Jersey population science researcher XiangLin Tan, MD, PhD, has been awarded an $852,705 Career Development Award (K07CA190541) from the National Cancer Institute to explore the use … Continue reading






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Diabetes drug metformin modulates cholesterol levels: Helmholtz Zentrum München, German Research Center for Environmental Health






The DZD-researchers at Helmholtz Zentrum München and German Diabetes Center Düsseldorf analyzed more than 1.800 blood samples of participants, who joined the German large-scale study KORA*. Using a comprehensive approach, the scientists investigated metabolic products (metabolites) as well as genetics … Continue reading






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The Role of Aspirin, Vitamin D, Exercise, Diet, Statins, and Metformin in the Prevention and Treatment of Colorectal Cancer






Curr Treat Options Oncol. 2015 Sep;16(9):359. doi: 10.1007/s11864-015-0359-z. The Role of Aspirin, Vitamin D, Exercise, Diet, Statins, and Metformin in the Prevention and Treatment of Colorectal Cancer. Sehdev A1, O’Neil BH. Author information 1Division of Hematology Oncology, Department of Medicine, … Continue reading






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Diabetes medications reduce dementia risk






Patients with type 2 diabetes have a dysfunctional sugar metabolism because the essential hormone insulin does not work effectively. Once the disease reaches an advanced stage, the body stops producing insulin altogether, which means that it has to be administered … Continue reading






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Why Widely Used Type II Diabetes Drugs Make People Fat: George State University






Newswise — ATLANTA—Medication used to treat patients with type II diabetes activates sensors on brain cells that increase hunger, causing people taking this drug to gain more body fat, according to researchers at Georgia State University, Oregon Health and Science … Continue reading






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Onion extract may improve high blood sugar and cholesterol: Delta State U study






San Diego, CA- The extract of onion bulb, Allium cepa, strongly lowered high blood glucose (sugar) and total cholesterol levels in diabetic rats when given with the antidiabetic drug metformin, according to a new study. The study results will be … Continue reading






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The Effect of Metformin on Glucose Homeostasis During Moderate Exercise






Published online before print December 2, 2014, doi: 10.2337/dc14-1480 Diabetes Care February 2015 vol. 38 no. 2 293-301 Merethe Hansen⇑, Marie K. Palsøe, Jørn W. Helge and Flemming Dela - Author Affiliations Xlab, Center for Healthy Aging, Department of Biomedical … Continue reading






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Overly Conservative FDA Label Likely Prevents Use of Metformin in Many Type 2 Diabetics






Newswise — PHILADELPHIA—Many patients with type 2 diabetes in the United States may be discouraged from taking metformin—a proven, oral diabetes medicine—because the U.S. Food and Drug Administration inappropriately labels the drug unsafe for some patients also suffering from kidney … Continue reading






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How type 2 diabetics can live longer than people without the disease






Patients treated with a drug widely prescribed for type 2 diabetes can live longer than people without the condition, a large-scale study involving over 180,000 people has shown. The findings indicate that a drug known as metformin, used to control … Continue reading






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For diabetics, metformin and SGLT2 inhibitors together are better than either alone






Metformin* and SGLT2 inhibitors** together reduce the blood sugar levels considerably more effectively than either drug alone. Scientists from the Helmholtz Zentrum München, partner in the German Center for Diabetes Research, report in the journal ‘Diabetes’ that this is due … Continue reading






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Metformin may not have the anti-cancer effects that have been described






Metformin, a biguanide derived from the French lilac, has become the preferred first-line therapy for the treatment of type 2 diabetes (1). This drug is inexpensive, has an excellent safety profile, and can be safely combined with other antidiabetes agents … Continue reading






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Diabetes drug slows aging and lengthens lifespan: Proceedings of the National Academy of Sciences






A study by Belgian doctoral researcher Wouter De Haes (KU Leuven) and colleagues provides new evidence that metformin, the world’s most widely used anti-diabetic drug, slows ageing and increases lifespan. In experiments reported in the journal Proceedings of the National … Continue reading






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