There’s a lot of evidence that taking low doses of aspirin daily can help heart attack patients avoid a second event. Aspirin’s ability to reduce inflammation and keep blood from forming vessel-blocking clots can be a life-saver. But what about the many Americans who take it daily hoping to avoid a first heart attack or stroke? The data there is more conflicting, and a large new study in JAMA published Monday suggests it may not make much of a difference.
The Food and Drug Administration recently said there was not enough evidence to support the idea that aspirin can prevent a first heart attack. So researchers in Japan decided to investigate the issue among 14,646 volunteers between the ages of 60 years and 85 years. Between 2005 and 2007, these participants, none of whom had had any heart events, but all of whom had at least one of the risk factors that could make them vulnerable, were randomly assigned to take a low-dose aspirin every day or not. They were allowed to continue taking whatever medications they were already or, or begin taking new drugs if their doctor prescribed them during the study.
Now, reporting in JAMA, scientists say that after five years, the study’s review board ended the trial when it was clear that there were no significant differences between the two groups when it came to heart attacks, strokes, other heart events or death. More